Dr. CH_KIm Home
◀◀
        처음으로 ㅣ  병원 자료 ㅣ  의학 자료 ㅣ  태그 자료 ㅣ  일반 자료 ㅣ  음악 자료 ㅣ  일정표 |  북마크
의학 자료

CATEGORY
초음파 (29)
산과 (18)
불임, 피임 (27)
부인과 (32)
생식기 내분비학 (23)
상용약 약전 (24)
Lab (참고치) (9)
교육용 자료 (47)
의학 뉴스 (13)
비만 (5)
Relation of nutrients and hormones in polycystic ovary syndrome
Sidika E Kasim-Karakas1, Wendy M Cunningham1 and Alex Tsodikov1

1 From the Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, University of California, Davis, Davis, CA (SEK-K); the Department of Biostatistics, School of Public Health, University of Michigan at Ann Arbor, Ann Arbor, MI (AT); and the Department of Nutrition, Family and Consumer Sciences, California State University, Sacramento, CA (WMC)

Background: Insulin resistance, infertility, and hirsutism,>common characteristics of polycystic ovary syndrome (PCOS),>improve with even modest weight loss. Optimal dietary treatment>for PCOS is not known.>

Objective: We compared the effects of acute protein administration>with those of glucose challenges on hormones related to obesity>and insulin resistance (ie, cortisol and insulin), hirsutism>[ie, dehydroepiandosterone (DHEA) and androstenedione], and>hunger (ie, ghrelin).>

Design: Patients with PCOS (n = 28; aged 26 ± 2 y) were>tested with a 5-h oral-glucose-tolerance test (OGTT) and a euvolemic,>euenergetic protein challenge.>

Results: Glucose ingestion caused larger fluctuations in blood>glucose and more hyperinsulinemia than did protein (P < 0.01,>overall treatment-by-time interaction). During the protein challenge,>cortisol and DHEA declined over 5 h. During OGTT, cortisol and>DHEA increased after the third hour and began to show significant>divergence from protein from the fourth hour (P 0.01). During>OGTT, 18 patients who had a blood glucose nadir of <69 mg/dL>had elevated cortisol (baseline: 10.4 ± 0.4; nadir: 5.9>± 0.1; peak: 12.7 ± 0.9 µg/dL) and DHEA>(baseline: 15.6 ± 1.3; nadir: 11.2 ± 1.0; peak:>24.6 ± 1.6 ng/mL) (P < 0.01), whereas the remaining>10 patients with a glucose nadir of 76 ± 2 mg/dL had>no increase in adrenal steroids. Both glucose and protein suppressed>ghrelin (from 935 ± 57 to 777 ± 51 pg/mL and from>948 ± 60 to 816 ± 61 pg/mL, respectively). After>glucose ingestion, ghrelin returned to baseline by 4 h and increased>to 1094 ± 135 pg/mL at 5 h. After the protein challenge,>ghrelin remained below the baseline (872 ± 60 pg/mL)>even at 5 h. The overall treatment effect was highly significant>(P < 0.0001).>

Conclusions: Glucose ingestion caused significantly more hyperinsulinemia>than did protein, and it stimulated cortisol and DHEA. Protein>intake suppressed ghrelin significantly longer than did glucose,>which suggested a prolonged satietogenic effect. These findings>provide mechanistic support for increasing protein intake and>restricting the simple sugar intake in a PCOS diet.

  목록보기

  Editor | 산과계산기 |영어회화 관리자 | 주소록 | 웹하드  
Copyright 2003-2016 drchkim.com All rights reserved.